BRI3
[brain protein I3] The expression of the gene encoding this protein is upregulated in cells treated with TNF-alpha (Wu et al, 2003). Overexpression of BRI3 induces cell death by apoptosis in L929 cells. Blocking expression by using an antisense oligonucleotide promotes resistance to TNF-alpha induced cell death by more than 1000-fold. The mechanism of action of this protein remains to be elucidated but BRI3 may be localized to, and function through, lysosomes.
Matsuda S et al (2009) have reported that BRI3 is an endogenous negative regulator of the production of abeta-amyloid peptide, a peptide that is cleaved off from
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