BRE
[brain and reproductive organ-expressed protein] The approved gene symbol is BABAM2 [BRISC and BRCA1 A complex member 2], and databank synonyms are BRCC4 [BRCA1/BRCA2-containing complex subunit 4] OR BRCC45 (referring to its molecular mass of 45 kDa).
The gene encoding this protein (383 amino acids) has been identified by Li et al (1995) in human cells. The gene is expressed highly in brain and reproductive organs. Expression is responsive to DNA damage and retinoic acid treatment. Treatment of fibroblasts, brain glioma cells, the promyelocytic cell HL-60, or squamous carcinoma
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