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BRCC2

[breast cancer cell 2] This intronless human gene on chromosome 11q24.1 has been identified by Broustas et al (2004). BRCC2 is identical with BLID [BH3-like motif-containing cell death inducer].

The protein (108 amino acids) contains a BH3 domain. The protein is localized predominantly in the cytosol and to a lesser extent in mitochondria. Ectopic expression of BRCC2 in eukaryotic cells causes cell death by apoptosis and coincides with expression of caspase-3 and caspase-9. In human prostate cancer cells (PC-3), BRCC2-induced DNA-fragmentation can be blocked by co-expression of BCLxL ... ... ... ... ... Subscribe to continue reading! ... ...

 

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