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PC-3

[pheochromocytoma cell-3] The expression of this gene is induced in the rat PC12 cell line during neuronal differentiation by NGF. PC-3 is expressed in vivo in the neuroblast when it ceases proliferating and differentiates into a neuron. Overexpression of PC-3 in NIH 3T3 and PC12 cells leads to marked inhibition of cell proliferation. PC3 has been shown to potentiate differentiation induced by NGF and to protect neurons from cell death by apoptosis (Corrente et al, 2002, Montagnoli et al, 1996).

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