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BON

A permanent cell line derived from a metastatic human carcinoid tumor of the pancreas (Evers et al, 1991; Parekh et al, 1994). The cells produce tumors in nude mice. BON cells grow in monolayer culture and form colonies in soft agar (see also: Colony formation assay).

The cells express functional receptors for acetylcholine, 5-HT, isoproterenol, gastrin, and somatostatin. The cells overexpress N-ras and contain a homozygous point mutation of the N-ras gene. The cells also show increased expression of myc (Arany et al, 1994). The neu gene is amplified in these cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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