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BGEF

[B-cell derived growth enhancing factor] This biochemically uncharacterized factor of 60-65 kDa (gel filtration) is found in the conditioned medium of a human B-cell line established from the peripheral blood of a patient with rheumatoid arthritis.

BGEF enhances proliferation of peanut agglutinin nonagglutinated thymocytes induced by IL1. It also enhances production of IL2 induced by IL1 in thymocytes and a human T-cell clone, HSB.2 C5B2. BGEF alone does not induce the production of IL2. BGEF differs from BGEF-2.

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