BGEF |
BGF |
ubiquicidin |
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[B-cell derived growth enhancing factor-2] This biochemically uncharacterized activity of 15-20 kDa (gel filtration) was identified initially and purified as an IL2 enhancing factor enhancing the proliferation of CTLL-2 cells that depends on the presence of IL2 (see also: Factor-dependent cell lines).
The activity is produced by B-cells of patients with rheumatoid arthritis and systemic lupus erythematosus only when they are in the active stage of the disease. BGEF-2 enhances IL2 dependent growth of peripheral blood T-cells from patients with active rheumatoid arthritis but does not enhance the growth of T-cells from healthy volunteers.
BGEF-2 itself does not display
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