B7-2
also: B72. Also: [B-lymphocyte activation antigen B7-2].
A protein related to B7 and designated CD86 (Engel et al, 1994; Caux et al, 1994). The murine gene has been cloned by Freeman et al (1993).
B7-2 provides an important positive costimulatory signal on interaction with CD28 on resting T-cells (Engel et al, 1994). Interaction of B7-2 with CTLA-4 on recently activated cells can restrict responses of T-cells (Sharpe and Freeman, 2002; Abbas and Sharpe, 1999).
Related proteins form a larger protein family, members of which play important roles in cell-mediated immune responses by providing co-stimulatory signals to
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