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B4B

The cDNA for B4B has been isolated by Ruegg et al (1996). B4B is a membrane protein with 4 transmembrane domains. B4B shows approximately 40 % identity with a protein specific for Schwann cells that induces cell growth arrest, growth arrest-specific gene gas-3.

The protein is identical with TMP (tumor-associated membrane protein) (Ben-Porath et al, 1999), which is expressed highly in brain tumor cells but not in normal brain cells. Ben-Porath et al (1996) have shown that TMP is a myc target and is possibly involved in myc induced transformation. B4B is the same as EMP-1 (epithelial membrane protein-1 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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