Schwann cell precursors |
Schwann cell-specific EGF-like repeat autocrine factor |
NKp30 |
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[Schwann cell, Schwann cell-derived]
Schwann cells are specialized glial cells of the peripheral nervous system (Lobsiger et al, 2002). An older term for Schwann cells still in use is lemmocytes, and in older references the term neurolemmocytes may refer to Schwann cells. Schwann cells develop from neural crest cells in several discrete developmental steps. A number of specific transcription factors are associated with these transitions. For example, Krox-24 expression is restricted to Schwann cell precursors, whereas Krox-20 expression is observed in mature Schwann cells. At birth, Krox-24 is reactivated and the two genes are coexpressed. In the adult, Krox-20
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