ATG1B |
ATG4A |
secreted and transmembrane 1 |
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[autophagy-related-3] (approved gene symbol) Other designations for this protein are APG3 [autophagy gene 3] and APG3L [APG3-like]. The protein has been described independently as PC3-96.
ATG3 is expressed ubiquitously and functions as a ubiquitin carrier protein E2-like enzyme during the initial stages of autophagy (autophagosome formation) by catalyzing the transfer of ATG7 bound ATG8 to phosphatidylethanolamine, the critical step for autophagy (Tanida et al, 2002; Hanada et al, 2007; Yamada et al, 2007). Human ATG3 displays the same enzymatic characteristics in vitro as yeast
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