AMBP-1 |
AMBRA1a |
Proteoglycan-4 |
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[Activating molecule in BECN1-regulated autophagy protein 1; autophagy/beclin-1 regulator 1] This protein has been identified independently as KIAA1736 and DCAF3 [Ddb1- and Cul4-associated factor 3]. A databank synonym is WDR94 [WD repeat domain 94].
Mouse AMBRA1 encodes a deduced 1,300 amino acid protein with an N-terminal WD40 domain. Human AMBRA1 encodes a deduced 1,269 amino acid protein (Fimia et al, 2007). Fimia et al (2007) have shown that human AMBRA1 binds to Beclin-1, a protein involved in the regulation of autophagosome formation during
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