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WD40 domain

[WD40 domains]

also: WD domain. The WD40 Domain has been observed as a structural motif of 40-43 amino acids in the beta subunit of G-proteins (Fong et al, 1986). It helps to form a circular propeller-like structure with a central pore (Lambright et al, 1996; Sondek et al, 1996; Garcia-Higuera et al, 1996). The seven blades of the propeller and the platform formed by them are potential binding surfaces for proteins and/or small ligands, which can bind either stably or reversibly (Smith et al, 1999).

WD40 repeats have been found in a number of eukaryotic proteins, including adaptor/regulatory modules in signal transduction, pre-mRNA processing, cytoskeleton assembly and cell cycle control (Paroush et al, 1994; Komachi and Johnson, 1997; Tyers and Jorgensen, 2000).

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