AIM2

[absent in melanoma 2] This protein contains a pyrin domain and a HIN domain and is being referred to in databanks also as PYHIN4 (see also: PYHIN family). Another databank synonym is Ifi210 [Interferon-inducible protein 210].

AIM2 is a cytoplasmic protein (Choubey et al, 2000). The human gene encodes a protein of 344 amino acids and has been cloned from a melanoma cell line in a screen for suppressors of melanoma tumorigenicity (DeYoung et al, 1997). DeYoung et al (1997) have reported that overexpression of AIM2 reverses the tumorigenic phenotype in a melanoma cell ... ... ... ...
 
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Entry last modified: September 2011