PYHIN4 |
PYK2 N-terminal domain-interacting receptor 1 |
FMGSALRIAAKVLPAALCQIFKKC |
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[pyrin and HIN domain-containing protein family] Members of this protein family are characterized by the presence of a pyrin domain and two DNA binding HIN domains. Members of this family are thought to act as sensors of microbial DNA and thus play a role as molecular pattern recognition receptors.
Individual members are involved in immune evasion but have different modes of action. For individual members see:
AIM2 [absent in melanoma 2] (PYHIN4)
IFIX [Interferon-inducible protein X] (PYHIN1)
IFI16 [interferon-induced protein 16 (PYHIN2
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