wingful

gene symbol: wf. This Drosophila melanogaster gene (CG13076) has been identified by Gerlitz and Basler (2002). wingful encodes a secreted potent extracellular feedback inhibitor of Wingless, a secreted signaling protein that acts as a morphogen to pattern the imaginal discs of Drosophila. Wingful functions during larval stages and is thought to provide feedback control for the long-range morphogen activities of wingless.

Independently, Giráldez AJ et al (2004) have identified the same secreted repressor of wingless activity and referred to it as NOTUM. Loss of NOTUM function leads to increased Wingless activity by altering the shape of the ... ... ... ...
 
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Entry last modified: January 2020