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vIL18BP

[viral IL18 binding protein] This protein is shown to be secreted into the conditioned medium of cells infected with vaccinia (vaccinia virus C12L gene; Born et al, 2000), ectromelia and cowpox viruses (Calderara et al, 2001; Smith et al, 2000). The ectromelia virus protein (referred to as E19) blocks NF-kappa-B activation and induction of IFN-gamma in response to IL18 (Smith et al, 2000). The vaccinia virus vIL18BP has been shown to inactivate IL18 and inhibits NK-cell responses (Born et al, 2000). Symons et al (2002) have reported that this protein promotes virus virulence.

For other viral proteins binding to IL18 see also: ectromelia poxvirus p13 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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