synonyms |
synovial endothelium targeting peptide |
Hetrin |
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Gene symbol SYVN1. The gene has been identified independently as KIAA1810. The protein has been identified as Synoviolin in rheumatoid synovial cells (Amano et al, 2003). Gao et al (2006) have reported that pro-inflammatory cytokines, including TNF-alpha and IL1-beta induce the expression of synovial apoptosis inhibitor 1 in synovial fibroblasts. The protein is a mammalian endoplasmic reticulum E3 ubiquitin ligase (Nadav et al, 2003).
Chen et al (2012) have reported that over-expression of synovial apoptosis inhibitor 1 stimulates the proliferation of synoviocytes
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