shepherd cells |
Shepherdin(79-83) |
slit guidance ligand 3 |
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This is the name given to a fragment of the anti-apoptotic and mitotic regulator survivin, corresponding to Survivin(79-87) (Plescia et al, 2005). In some publications the peptide is being referred to also as survivin antagonistic peptide.
The sequence of Shepherdin, KHSSGCAFL, constitutes the minimum sequence of the binding interface between survivin and the molecular chaperone hsp90 that blocks the interaction between survivin and hsp90 (Fortugno et al (2003). Plescia et al (2005) have reported that a shepherdin fusion peptide containing either the Penetratin
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