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schistocytes

[schistocyte]

This cell type occurs as a result of erythrocyte fragmentation (Lesesve et al, 2005). The presence of such fragmented cells is due to mechanical injury and thus is an important diagnostic marker for thrombotic microangiopathies (Klein et al, 1975; Ward, 1979.

Bunyaratvej et al (1985) have reported reduced numbers of normally shaped erythrocytes (see: discocytes) in patients with beta-thalassemia/HbE disease, which is reduced further by splenectomy, larger splenic sizes, and increasing anemia. The numbers of dacryocytes, keratocytes, and schizocytes depends on the splenic status. Larger splenic size is associated with an increased number of schistocytes, whereas splenectomy is associated with a noticeable reduction in their numbers.

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