Paraaortic splanchnopleura |
paracaspase-1 |
protein tyrosine phosphatase nonreceptor type substrate 1 |
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Parabutoporin (FKLGSFLKKAWKSKLAKKLRAKGKEMLKDYAKGLLEGGSEEVPGQ) is a pore-forming peptide previously isolated from the venom of the South-African scorpion Parabuthus schlechteri. For a related peptide see also: Im-1. The peptide is active against Gram-negative bacteria (Moerman et al, 2002).
Moerman et al (2003) have reported that the peptide induce Ca(2+) signaling in HL-60 (promyelocytic leukemia) cells.
Parabutoporin has been shown to induce chemotaxis of neutrophils via a pertussis toxin-sensitive way and to reduce strongly the superoxide production by the NADPH oxidase complex after either PMA or fMLP
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