nov

[nephroblastoma overexpressed gene] This proteins is not related to NOV. The nov gene has been identified originally as an embryonic gene encoding a secreted potential IGF binding protein the expression of which is upregulated in virally-induced avian nephroblastomas (Soret et al, 1989; Joliot et al, 1992). Homologous sequences are conserved in human DNA (designated novH) and are expressed in normal human bone marrow, thymic cells and in one nephroblastoma (Martinerie and Perbal, 1991). For a bioactive cryptic peptide fragment of nov see: Nephroblastostatin.

nov is a member of the CCN family ... ... ... ...
 
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Entry last modified: November 2008