My033 |
myb induced myeloid protein-1 |
SELL |
||
c-myb is the cellular counterpart of the transforming oncogene v-myb of avian myeloblastosis virus and the E26 leukemia virus, which cause myeloid leukemia in chicken. The human gene maps to 6q22-6q23. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas.
The myb gene encodes a nuclear protein involved in transcriptional regulation (see also: gene expression). The DNA-binding domain of myb recognizes a specific myb-responsive element with the consensus sequence (C/T)G(A/G((A/C/G)GTT(A/G). See also:
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |