hippo

The Drosophila melanogaster gene hippo (abbr. hpo; gene CG11228) encodes a protein kinase most related to mammalian MST1 (not identical with HGF-like protein but identical with serine/threonine protein kinase 4; STK4) and MST-2. Mutations of hippo cause increased tissue growth and impaired cell death by apoptosis. Cells with a mutated hippo gene express elevated levels of the cell cycle regulator cyclin E and the apoptosis inhibitor DIAP1. This effect is similar to that seen with salvador. hippo has been shown to interact with salvador ... ... ... ...
 
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Entry last modified: August 2003