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hippo

The Drosophila melanogaster gene hippo (abbr. hpo; gene CG11228) encodes a protein kinase most related to mammalian MST1 (not identical with HGF-like protein but identical with serine/threonine protein kinase 4; STK4) and MST2. Mutations of hippo cause increased tissue growth and impaired cell death by apoptosis. Cells with a mutated hippo gene express elevated levels of the cell cycle regulator cyclin E and the apoptosis inhibitor DIAP1. This effect is similar to that seen with salvador. hippo has been shown to interact with salvador. Hippo also interacts with another ... ... ... ... ... Subscribe to continue reading! ... ...

 

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