GHN |
ghost cells |
MAPK/ERK signalling |
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[glioma homing peptide] This peptide, NHQQQNPHQPPM, has been identified by phage display library screening of a random peptide libraty (Eriste et al, 2013) as a tumor homing peptide that selectively recognizes glioma cells (see also: cell-penetrating peptides). When conjugated to the cell-penetrating peptide pVEC and a cytotoxic agent, doxorubicin, this construct is taken up efficiently by glioma cells and glioma xenograft tumors in a mouse model. Vectorized doxorubicin is more efficient than the free drug in a mouse glioma xenograft model after systemic administration of the drugs. See also: Glioma-homing peptide
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