frizzled-6 |
frizzled-8 |
SWDIAWPPLKVP |
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[frizzled family receptor 7] this is a mammalian homolog of the Drosophila melanogaster frizzled proteins, which are known to interact with Wnt family proteins. frizzled-7 (574 amino acids) is a secreted protein that is known also as FzD7 or Fz7 (Sagara et al, 1998) or FzE3 (Tanaka et al, 1998). Tanaka et al (1998) have reported that frizzled-7 is expressed specifically in esophageal carcinoma tissue and generally correlates with the development of poorly differentiated highly metastatic tumors. Tanaka et al (1998) have suggested that frizzled-7 may downregulate the APC tumor suppressor gene, mutations of which are observed frequently in human
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