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Frizzled

Abbr. Fz (gene: CG17697); also: frizzled-1. The Frizzled gene of Drosophila melanogaster is essential for the development of normal tissue polarity in the adult cuticular structures (Wang et al, 1996; Sagara et al, 1998). The protein belongs to the seven transmembrane class of receptors (7TMR). Its extracellular region contains a cysteine-rich domain with a characteristic spacing of ten cysteines. This sequence motif can be found in a variety of otherwise unrelated proteins.

Frizzled is a member of a gene family that is conserved in vertebrates and invertebrates (Rattner et al, 1997). Frizzled homologous proteins have been identified in other species including mammals, ... ... ... ... ... Subscribe to continue reading! ... ...

 

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