dnr1

[Defense repressor 1] this Drosophila melanogaster protein is encoded by gene CG12489. Foley E and O'Farrell (2004) have reported that dnr1 has characteristics of an inhibitor of apoptosis protein dnr1 stability is controlled by DREDD in a negative feedback loop that restricts DREDD function. dnr1 also prevents activation of the Relish transcription factor.

Primrose DA et al (2007) have reported that dnr1 functions as an inhibitor of initiator caspases and regulates cell death by apoptosis through regulating the expression of DRONC. Depletion of dnr1 elevates DRONC protein levels, whereas overexpression of Dnr1 reduces ... ... ... ...
 
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Entry last modified: May 2021

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: Innate immunity and defense peptides Dictionary.