Dicentracin |
dickkopf-2 |
Immune-induced Molecule 29 |
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(from German dick =thick; Kopf = head) abbr. dkk-1. Also: dickkopf-related protein 1 or dickkopf homolog 1. Dickkopf-1 has been identified independently as Sk. The protein (266 amino acids) contains two distinct cysteine-rich domains in which the positions of 10 cysteine residues are highly conserved between members of the dickkopf family (Krupnik et al, 1999). A comparison of genomic sequences of dickkopf-1 from various rodents and mammals has been described by Katoh and Katoh (2005).
Dickkopf-1 is a glycoprotein identified initially as a secreted inducer of Spemann's organizer in the early Xenopus laevis gastrula (Glinka et al, 1993). An ortholog of this gene has been found in other species, including
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