SK |
SK-12 |
Tyr-MIF-1 |
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This secreted human protein co-elutes with Neuregulin during chromatographic separation of conditioned medium from the SK-LMS-1 human leiomyosarcoma cell line. When coexpressed with Wnt-2 in NIH 3T3 cells, human Sk causes reversion of Wnt-2 induced morphological alterations and inhibits the Wnt-2 induced increase in uncomplexed beta-catenin levels. Sequence analysis shows that Sk is identical with dickkopf-1 (Fedi et al, 1999).
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