bunched
abbr. bun. Bunched is a Drosophila gene (CG42281) that has been shown to play a role in peripheral nervous system and eye development (Treisman et al, 1995). The gene has been identified independently as a sequence homologous to the mammalian growth factor-stimulated TSC-22 [TGF-beta-stimulated clone-22] gene expressed in anterodorsal follicle cells during oogenesis. bunched is required for the proper elaboration of dorsal cell fates leading to the formation of the dorsal appendages (Dobens et al, 1997).
Bunched is necessary for cellular growth, proliferation, and survival both in culture and in an epithelial context. It prevents recruitment of epithelial cells
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