biTregs

[bifunctional Tregs; bifunctional regulatory T-cells] This specific subset of T-cells, constituting regulatory T-cells with both regulatory and pro-inflammatory functions, is characterised by the simultaneous expression of FoxP3, a master transcription factor for regulatory T-cells, and ROR-gamma-t, a master regulator of Th17 cells (Lochner et al, 2008; Ayyoub et al, 2009; Kluger et al, 20125). The cells, termed also ROR-gamma-t(+) FoxP3(+) T-cells or ROR-gamma-t(+) FoxP3(+) biTregs, produce the pro-inflammatory cytokine IL17 and at the same time secrete high amounts of immunoregulatory ... ... ... ...
 
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Entry last modified: August 2019