bFGF inducing activity

[bFGF/uPA inducing activity; urokinase plasminogen activator inducing activity] This biochemically uncharacterized factor of approximately 18 kDa is found in conditioned medium by human SK-Hep1 hepatoma cells or mouse S180 sarcoma cells. The activity rapidly upregulates endothelial cell expression of bFGF and induces the formation of capillary-like structures by vascular endothelial cells grown on three-dimensional fibrin gels (in vitro angiogenesis).

The activity also induces endothelial cells to increase expression of urokinase plasminogen activator (uPA ... ... ... ...
 
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Entry last modified: March 2002