awd

[abnormal wing disk] The Drosophila melanogaster protein awd, encoded by gene CG2210, shows 78 % homology with mammalian nm23 and is considered the ortholog of nm23. awd has been shown to possess Nucleoside diphosphate kinase activity (Biggs et al, 1990; Lascu et al, 1992).

The disruption of awd function arrests cells in the metaphase. The protein is associated with the microtubules and plays a role in the polymerization of spindle fibers. Loss of awd in the fly results in dysregulated tracheal cell motility, a phenotype that can be suppressed by reducing the dosage of the chemotactic FGF homolog breathless ... ... ... ...
 
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Entry last modified: August 2013