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astrocyte mitogen inhibitor

This biochemically uncharacterized soluble protein isolated from rat brain is immunologically related to the EGF receptor. Levels of this inhibitor drop after injury to the brain and this coincides with the appearance of EGF receptors on astrocytes. Intracerebral injection of neutralizing antibodies cause the appearance of numerous reactive astrocytes (Nieto-Sampedro et al, 1988).

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