XCP4 |
X-determinant |
Meth A factor |
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[XC chemokine receptor-1] This receptor has been cloned by Yoshida et al (1998) who also proposed the name. The receptor is identical with GPR5 [G-protein-coupled receptor-5] and has been shown to bind the chemokine SCM-1 (lymphotactin) (thus also being referred to as lymphotactin receptor). Shan et al (2000) have shown that viral MIP-2 (vCCL2 [viral CCL2]) encoded by KSHV binds to XCR1. Lüttichau et al (2007) have reported that vCCL3 (vMIP-3 [viral MIP-3]), also encoded by KSHV, is a highly selective agonist XCR1. The potency of
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