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WW domain

[WW domains]

The WW domain is a protein-protein interaction module composed of 35-40 amino acids and recognized originally in dystrophin and various other proteins (Chen and Sudol, 1995; Bork and Sudol, 1994). The name is derived from two conserved Tryptophan residues spaced 20 to 22 residues apart within the consensus sequence.

The domain binds ligands containing proline-rich sequences such as PPPPY, PPPNY and PPLP. (Sudol and Hunter, 2000) (for structurally unrelated but functionally similar domains see also: GYF domain, SH3). The largest class of WW domains binds ligands containing PPxY motif ... ... ... ... ... Subscribe to continue reading! ... ...

 

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