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WISP-2

[Wnt-1 induced secreted protein-2; Wnt1-inducible signaling pathway protein-2] WISP-2 has been identified as a gene the expression of which is upregulated in the mouse mammary epithelial cell line C57MG transformed by Wnt-1, but not by Wnt-4. The gene is expressed also in vascular smooth muscle cells.

The WISP-2 maps to human chromosome 20q12-20q13. Human WISP-2 (250 amino acids) is a secreted protein that is 73 % identical to the mouse protein. WISP-2 is a member of the CCN family of growth factors and has been given the designation CCN5 (see also: CCN family ... ... ... ... ... Subscribe to continue reading! ... ...

 

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