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W/Wv mice

[WWv mouse]

These mice carry a mutation in the kit oncogene (SCF receptor) (CD117) (Nocka et al, 1990). The particular Wv allele, Kit(Wv), [viable dominant spotting; dominant white spotting] arose spontaneously in the C57BL/6J strain. Some homozygotes have a near-normal life span (Little and Cloudman, 1937; Russel, 1949; Fekete et al, 1941).

Kit(W) homozygous mice (Kit(W/W) genotype) lack the kit receptor and with rare exceptions, are not viable (Galli and Kitamura, 1987; Waskow et al, 2002) and can be used, therefore, only for in vitro studies, for example, for the analysis of the development of mature ... ... ... ... ... Subscribe to continue reading! ... ...

 

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