VSDL |
V-set and immunoglobulin domain containing 3 |
AATYK1 |
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[very small embryonic-like stem cells] This cell type has been identified by Kucia et al (2006) in murine bone marrow. These cells constitute a homogenous population of rare (approximately 0.02% of bone marrow mononuclear cells) Sca-1(+) lin(-) CD45(-) cells that express markers of pluripotent stem cells such as SSEA-1, OCT4, NANOG, and Rex-1. VSEL-SC are significantly smaller than hematopoetic stem cells (approximately 2-4 micrometers), possess large nuclei surrounded by a narrow rim of cytoplasm, and contain open-type chromatin (euchromatin) that is typical for embryonic stem cells
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