VP5

VP5 is encoded by a 5'-terminal, small open reading frame in segment A of the aquatic birnavirus (infectious pancreatic necrosis virus, IPNV) genome. VP5 is a nonstructural protein (17 kDa) that contains BCL2 homology domains BH1, BH2, BH3, and BH4. VP5 expression enhances the functional half-life of the anti-apoptotic survival factor MCL1 and regulates specific viral protein expression during the early replication cycle. VP5 also enhances cell viability after UV irradiation.

Lin et al (2005) have shown that VP5 is capable of enhancing insect cell viability by inhibiting apoptosis of insect cells infected with baculovirus.

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Entry last modified: January 2013