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VP35

[Ebola viral protein 35] This protein is encoded in the genome of Ebolavirus, which causes severe hemorrhagic fever in both humans and nonhuman primates, with fatality up to 90 %. It is one of the proteins essential for virus replication (Mühlberger et al, 1999). The protein has been shown to function as an antagonist of type 1 interferons and may be an important determinant of Ebola virus virulence in vivo (Basler et al, 2000). The Ebola virus VP35 protein inhibits IRF3, a cellular transcription factor of central importance in initiating host cell IFN responses. VP35 protein has been shown to block the production of IFN-alpha and IFN-beta (Cardenas et al, 2006) by binding dsRNA, a key ... ... ... ... ... Subscribe to continue reading! ... ...

 

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