VIRIP

[virus-inhibitory peptide] This peptide has been isolated by Münch et al (2007) from human hemofiltrate fractions. The peptide, LEAIPMSIPPEVKFNKPFVF (Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-Pro-Glu-Val-Lys-Phe-Asn-Lys-Pro-Phe-Val-Phe), corresponds to residues 353-372 of human alpha-1-antitrypsin (abbr. alpha-1-antitrypsin(353-372), SERPINA1(353-372)), the most abundant circulating serine protease inhibitor (Travis and Salvesen, 1983). VIRIP inhibits infection and transmission of a wide variety of HIV-1 strains, including strains that are resistant to antiretroviral drugs and acts by blocking HIV-1 entry by interacting with the gp41 fusion ... ... ... ...
 
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Entry last modified: August 2014