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Uromodulin

abbr. URO; approved gene symbol: UMOD. This glycoprotein (name suggested by Muchmore and Decker, 1986) of 85 kDa (639 amino acids including a signal sequence of 24 amino acids), called also Uromucoid, was initially found in the urine of pregnant women and identified as an inhibitor of viral hemagglutination (Tamm and Horsfall, 1950; for purification see: Serafini-Cessi F et al, 1989). It is produced by kidney cells of Henle's loop (Bachmann et al, 1990). Uromodulin is secreted also by HLA-DR monocytes and the neo-fibroblasts that derive from them (Labat et al, 1991. Bringuier et al, 1992).

The protein has been identified independently as HGP92.

The protein is identical with THP ... ... ... ... ... Subscribe to continue reading! ... ...

 

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