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URB

[upregulated in Brs3-deficient mice] This gene (gene symbol: CCDC80 [coiled-coil domain containing 80]) has been identified by Aoki et al (2002). Expression is upregulated specifically in knock-out mice lacking expression of the gene encoding bombesin-like receptor-3 (BRS3), a mouse strain that exhibits mild late-onset obesity, hyperphagia, and reduced metabolic rates.

URB (949 amino acids) is a secretory protein but also contains a nuclear localization signal.

Mouse URB appears to be the homolog of rat SSG1 [steroid-sensitive gene-1] (>90 % identity), but several mismatches result in a frameshift, and the ... ... ... ... ... Subscribe to continue reading! ... ...

 

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