UL144
[Cytomegalovirus UL144 protein] an open reading frame found in clinical isolates of human CMV. It encodes a structural homolog of the herpesvirus entry mediator (HVEM), a member of the TNF receptor superfamily. The protein is called also immune evasion viroceptor-1.
Cheung et al (2005) have reported that UL144 binds BTLA [B and T-lymphocyte attenuator], but not LIGHT, and inhibits T-cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM [Herpesvirus entry mediator].
UL144 can induce NF-kappa-B activation and modulate host
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