Trirusin |
TrissinR |
UNC-112 related protein 2 |
||
(so named because it contains three disupfide bonds) is a cysteine-rich non-amidated insect neuropeptide (IKCDTCGKECASACGTKHFRTCCFNYL; Ile-Lys-Cys-Asp-Thr-Cys-Gly-Lys-Glu-Cys-Ala-Ser-Ala-Cys-Gly-Thr-Lys-His-Phe-Arg-Thr-Cys-Cys-Phe-Asn-Tyr-Leu) identified originally in Drosophila melanogaster (gene: CG14871). Trissin activates the G-protein-coupled receptor TrissinR [Trissin receptor] (gene: CG34381) in vitro, leading to increased intracellular calcium ion levels. Trissin and its receptor are expressed predominantly in the brain and thoracicoabdominal ganglion (Ida et al, 2011).
Trissin and trissin-related neuropeptides
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