TRIM29

(approved gene symbol) [tripartite motif-containing protein 29] This protein, a member of a large family of proteins containing a tripartite motif, is known also as ATDC [Ataxia-Telangiectasia group D-Complementing protein], having been discovered originally in cells from Ataxia Telangectasia patients owing to its capacity to induce resistance to ionizing radiation in these cells (Leonhardt et al, 1994). Knock-down of TRIM29 sensitizes cells to UV irradiation. Bertrand-Vallery V et al (2010) have shown that TRIM29 serves as a survival factor in keratinocytes. It is expressed abundantly in keratinocytes following UVB exposure, treatment with DNA ... ... ... ...
 
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Entry last modified: September 2023