TNFRSF12
[TNF receptor superfamily member 12] Systematic designation, based on sequence similarity with the TNF-alpha receptor, for APO-3, DR3, LARD, TR3, TRAMP, wsl-1
Wang et al (2001) have generated knock-out mice lacking expression of TNFRSF12. These studies implicate the receptor in the removal of self-reactive T-cells in the thymus. Developmental defects or defects in the early development of thymocytes have not been observed, but negative selection and anti-CD3 induced apoptosis of thymocytes is impaired significantly, while superantigen induced negative selection and positive selection are normal. Note:
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