TLP
[TRAP-1-like protein] This signaling protein modulates the effects of TGF-beta (Gelici et al, 2003). The protein binds to the intracellular domain of TGF-beta receptors and activin type 2 receptors. It contributes to cellular specificity of TGF-beta transcriptional responses by interfering with binding of several SMAD proteins.
Caplan et al (2001) have cloned the human cDNA, referring to the protein as Vam6p, which is the homolog of a protein found in Saccharomyces cerevisiae (see: Nakamura et al, 1997). The cDNA has been cloned
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